Training the Future Leaders in Genetics

We offer ACGME and ABMG accredited programs in biochemical genetics, clinical genetics, cytogenetics, and molecular genetics.

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Clinical Genetics Residency

Clinical Genetics Residency

Providing ACGME accredited residency programs in medical genetics and medical biochemical genetics.

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Laboratory Fellowship Programs

Laboratory Fellowship Programs

Offering ABMG accredited clinical laboratory training in molecular genetics, cytogenetics, and biochemical genetics.

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Outstanding Faculty

Outstanding Faculty

Our dedicated group of amazing faculty thrive on educating and nurturing the next generation of genetic minds.

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 Advanced Human Genetics Course

            

 

The Advanced Human Genetics course is the major didactic component

of the Harvard Medical School Genetics Program. The year long course covers a wide variety of genetics topics taught by experts in the field.

 

Course Outline

             

 

Our Fellows in Press:

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2014. Epub 2014/11/05. doi: 10.1038/nature13835. PubMed PMID: 25363779.


 Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and cis-regulatory element annotations, derived by mapping RNA and chromatin in primary immune cells, including resting and stimulated CD4+ T-cell subsets, regulatory T cells, CD8+ T cells, B cells, and monocytes. We find that approximately 90% of causal variants are non-coding, with approximately 60% mapping to immune-cell enhancers, many of which gain histone acetylation and transcribe enhancer-associated RNA upon immune stimulation. 


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